Jones, Colin David; (2000) Aspects of infectious retinitis in immunocompetent and HIV infected people. Doctoral thesis (M.D), UCL (University College London).

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Abstract

Various issues associated with infectious retinitis in both the immunocompetent and immunocompromised patient are examined. With the introduction of Highly Active Anti-retroviral therapy (HAART), the clinical manifestations of AIDS are changing. Patient survival is increasing with the lowering of HIV antigenaemia, and the recovery of CD4+ cell numbers. It remains unknown, however, whether the numerical increase is paralleled by a concomitant recovery in immune function. An investigation was undertaken into the survival of patients with CMV retinitis both before and after the introduction of HAART. The clinical appearance of retinitis associated with various aetiological agents is changing and is less well characterised than before. The role of molecular biology is therefore becoming increasingly important as a diagnostic aid, and in this context, the role of the polymerase chain reaction (PCR) in the diagnosis of Toxoplasma (T. gondii) retinochoroiditis by the amplification of DNA from various ocular samples has been investigated. Given that most HIV/AIDS is in the developing world, ocular aspects of AIDS both in the profoundly immunosuppressed and in those patients who have not long seroconverted are described in a population cohort from a rural population in Uganda.

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