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Identifying Patterns of Breast Cancer Genetic Signatures using Unsupervised Machine Learning

Hamoudi, R; Bettayeb, M; Alsaafin, A; Hachim, M; Nassir, Q; Nassif, AB; (2019) Identifying Patterns of Breast Cancer Genetic Signatures using Unsupervised Machine Learning. In: Proceedings of 2019 IEEE International Conference on Imaging Systems and Techniques (IST). IEEE: Abu Dhabi, United Arab Emirates. Green open access

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Abstract

Deploying machine learning to improve medical diagnosis is a promising area. The purpose of this study is to identify and analyze unique genetic signatures for breast cancer grades using publicly available gene expression microarray data. The classification of cancer types is based on unsupervised feature learning. Unsupervised clustering use matrix algebra based on similarity measures which made it suitable for analyzing gene expression. The main advantage of the proposed approach is the ability to use gene expression data from different grades of breast cancer to generate features that automatically identify and enhance the cancer diagnosis. In this paper, we tested different similarity measures in order to find the best way that identifies the sets of genes with a common function using expression microarray data.

Type: Proceedings paper
Title: Identifying Patterns of Breast Cancer Genetic Signatures using Unsupervised Machine Learning
Event: 2019 IEEE International Conference on Imaging Systems and Techniques (IST)
ISBN-13: 9781728138688
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/IST48021.2019.9010510
Publisher version: http://dx.doi.org/10.1109/IST48021.2019.9010510
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10104657
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