Grellier, L. F L; (1998) Aspects of cellular and humoral immunity in chronic hepatitis C virus infection. Doctoral thesis (M.D), UCL (University College London).

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Abstract

Aims: To study various aspects of cellular and humoral immunity in chronic hepatitis C virus infection. Background: Chapter one provides an overview of hepatitis C virus (HCV) infection. Chapters two to four examine the evolution of CD4+ proliferative responses with anti-viral therapy in peripheral blood mononuclear cells in chronic HCV infection. In chapter five, I describe the attempts made to extract lymphocytes from cirrhotic liver tissue for functional studies. Chapter six correlates the presence or absence of anti-E2 HCV antibodies with viraemia and recombinant immunoblot assay response in a group of patients infected with HCV in 1977. Chapter seven evaluates and summarises the findings from these studies. Methods: Using recombinant HCV antigens, CD4+ T lymphocyte proliferative responses were examined prospectively in peripheral blood mononuclear cells from a cohort of patients with chronic HCV infection treated with ribavirin and interferon alpha. Attempts were made to extract and clone T lymphocytes from percutaneous liver biopsies and explanted liver tissue from HCV-infected patients for use in functional assays. The prevalence of antibodies to the E2 envelope protein of HCV was examined in a cohort of Irish women exposed to an identical innoculum of HCV in 1977.

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