Byrne, DJ; (1998) Effects of acute exercise, fitness training, and garlic supplementation on circulating markers of cardiovascular risk. Masters thesis (M.Phil), UCL (University College London).

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Abstract

The acute effects of a two-day Military Exercise (ME), following a sustained exercise program, on plasma levels of Fibrinogen, serum C-reactive Protein, Lp(a), lipids and glucose were investigated, together with the effects of long term garlic supplementation on plasma lipid profiles and oxidative status. Male British army recruits (n=318) were sampled at the start of their ten weeks basic training, and again over a five-day period following a strenuous two-day Military Exercise (ME) (n=206). The ME produced a rapid and significant increase in Fibrinogen concentration, lasting three days. CRP and Creatinine were also raised while Albumin was reduced during this period. Lp(a) levels showed little change at any of the sampling points. Cholesterol was reduced during the acute phase, but increased on days 4 and 5 post ME. Triglycerides increased gradually, while glucose concentrations were reduced in all recruits. Plasma samples were obtained for a second double blind study from general practice, in which garlic or placebo was administered for six months to fifty-one asymptomatic mildly hypercholesterolaemic volunteers. The copper ion induced lag time (oxidative resistance) of isolated LDL was significantly increased in both groups, but was not significantly different between groups, consistent with a 'placebo effect'. Lipid profiles were broadly unchanged. Other markers of oxidative resistance, Vitamin E concentration, LDL subfraction distribution, and levels of autoantibodies to oxidised LDL, did not correlate with the increase in lag time.

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