Kelkar, M;
Bohec, P;
Charras, G;
(2020)
Mechanics of the cellular actin cortex: From signalling to shape change.
Current Opinion in Cell Biology
, 66
pp. 69-78.
10.1016/j.ceb.2020.05.008.
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Abstract
The actin cortex is a thin layer of actin, myosin and actin-binding proteins that underlies the membrane of most animal cells. It is highly dynamic and can undergo remodelling on timescales of tens of seconds, thanks to protein turnover and myosin-mediated contractions. The cortex enables cells to resist external mechanical stresses, controls cell shape and allows cells to exert forces on their neighbours. Thus, its mechanical properties are the key to its physiological function. Here, we give an overview of how cortex composition, structure and dynamics control cortex mechanics and cell shape. We use mitosis as an example to illustrate how global and local regulation of cortex mechanics gives rise to a complex series of cell shape changes.
| Type: | Article |
|---|---|
| Title: | Mechanics of the cellular actin cortex: From signalling to shape change |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2020.05.008 |
| Publisher version: | https://doi.org/10.1016/j.ceb.2020.05.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Actin, Arp2/3, Cell mechanics, Cortex, Formin, Rho GTPases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10105442 |
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