McColgan, P;
Joubert, J;
Tabrizi, SJ;
Rees, G;
(2020)
The human motor cortex microcircuit: insights for neurodegenerative disease.
Nature Reviews Neuroscience
, 21
pp. 401-415.
10.1038/s41583-020-0315-1.
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Abstract
The human motor cortex comprises a microcircuit of five interconnected layers with different cell types. In this Review, we use a layer-specific and cell-specific approach to integrate physiological accounts of this motor cortex microcircuit with the pathophysiology of neurodegenerative diseases affecting motor functions. In doing so we can begin to link motor microcircuit pathology to specific disease stages and clinical phenotypes. Based on microcircuit physiology, we can make future predictions of axonal loss and microcircuit dysfunction. With recent advances in high-resolution neuroimaging we can then test these predictions in humans in vivo, providing mechanistic insights into neurodegenerative disease.
| Type: | Article |
|---|---|
| Title: | The human motor cortex microcircuit: insights for neurodegenerative disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41583-020-0315-1 |
| Publisher version: | https://doi.org/10.1038/s41583-020-0315-1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, AMYOTROPHIC-LATERAL-SCLEROSIS, HUNTINGTONS-DISEASE, PYRAMIDAL NEURONS, PREFRONTAL CORTEX, INTERNEURON DYSFUNCTION, INHIBITORY CONNECTIVITY, SYMPTOM HETEROGENEITY, LAMINAR ORGANIZATION, OSCILLATORY ACTIVITY, BETA-OSCILLATIONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10106489 |
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