Awad, A;
Fina, F;
Goyanes, A;
Gaisford, S;
Basit, AW;
(2020)
3D printing: Principles and pharmaceutical applications of selective laser sintering.
International Journal of Pharmaceutics
, 586
, Article 119594. 10.1016/j.ijpharm.2020.119594.
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Abstract
Pharmaceutical three-dimensional (3D) printing is a modern fabrication process with the potential to create bespoke drug products of virtually any shape and size from a computer-aided design model. Selective laser sintering (SLS) 3D printing combines the benefits of high printing precision and capability, enabling the manufacture of medicines with unique engineering and functional properties. This article reviews the current state-of-the-art in SLS 3D printing, including the main principles underpinning this technology, and highlights the diverse selection of materials and essential parameters that influence printing. The technical challenges and processing conditions are also considered in the context of their effects on the printed product. Finally, the pharmaceutical applications of SLS 3D printing are covered, providing an emphasis on the advantages the technology offers to drug product manufacturing and personalised medicine.
| Type: | Article |
|---|---|
| Title: | 3D printing: Principles and pharmaceutical applications of selective laser sintering |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpharm.2020.119594 |
| Publisher version: | http://dx.doi.org/10.1016/j.ijpharm.2020.119594 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 3D printed drug products, Additive manufacturing, Digital health, Gastrointestinal drug delivery systems, Personalized medicines, Powder bed fusion, Printlets |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10107342 |
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