Gallo, B;
Thaung, C;
Hay, G;
Arora, AK;
Cohen, VM;
Damato, B;
Sagoo, MS;
(2020)
Invasive conjunctival melanoma mimicking ocular surface squamous neoplasia: a case series.
British Journal of Ophthalmology
10.1136/bjophthalmol-2019-315393.
(In press).
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Abstract
BACKGROUND: Conjunctival melanoma is the second most common conjunctival malignant tumour after squamous cell carcinoma, usually arising from primary acquired melanosis and less commonly from a conjunctival naevus or de novo. We report four cases of conjunctival melanoma masquerading as ocular surface squamous neoplasia. METHODS: Four patients (2 females and 2 males; mean age 60.7 years; range 41-72 years) were referred for suspicious conjunctival lesions. In all cases, the lesions had a perilimbal location, were non-pigmented (cases 1 and 3) or mildly pigmented (cases 2 and 4), had a fleshy (cases 1, 2 and 4) or papillomatous (case 3) appearance and involved the corneal surface. In each case, our main clinical differential diagnosis included conjunctival intraepithelial neoplasia and squamous cell carcinoma. All four patients underwent an excisional biopsy with double freeze-thaw cryotherapy and alcohol keratoepitheliectomy. RESULTS: In all four cases, the histopathological diagnosis was of invasive conjunctival melanoma with extension to the deep surgical margins. Adjuvant therapy consisting of strontium-90 β radiotherapy (all 4 patients) and topical Mitomicyn C (patient 2) was administered. CONCLUSION: Conjunctival melanoma can clinically resemble ocular surface squamous neoplasia. Clinical impressions therefore need to be confirmed histopathologically.
Type: | Article |
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Title: | Invasive conjunctival melanoma mimicking ocular surface squamous neoplasia: a case series. |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1136/bjophthalmol-2019-315393 |
Publisher version: | https://doi.org/10.1136/bjophthalmol-2019-315393 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Conjunctiva, tumor, melanoma, ocular surface squamous neoplasia |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10107696 |
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