de Boer, RA;
Nijenkamp, LLAM;
Silljé, HHW;
Eijgenraam, TR;
Parbhudayal, R;
van Driel, B;
Huurman, R;
... van der Velden, J; + view all
(2020)
Strength of patient cohorts and biobanks for cardiomyopathy research.
Netherlands Heart Journal
, 28
pp. 50-56.
10.1007/s12471-020-01456-4.
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Abstract
In 2011 the Netherlands Heart Foundation allocated funding (CVON, Cardiovasculair Onderzoek Nederland) to stimulate collaboration between clinical and preclinical researchers on specific areas of research. One of those areas involves genetic heart diseases, which are frequently caused by pathogenic variants in genes that encode sarcomere proteins. In 2014, the DOSIS (Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches) consortium was initiated, focusing their research on secondary disease hits involved in the onset and progression of cardiomyopathies. Here we highlight several recent observations from our consortium and collaborators which may ultimately be relevant for clinical practice.
| Type: | Article |
|---|---|
| Title: | Strength of patient cohorts and biobanks for cardiomyopathy research |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s12471-020-01456-4 |
| Publisher version: | https://doi.org/10.1007/s12471-020-01456-4 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Cardiomyopathies, Gene variants, Patient cohorts |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108047 |
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