Leiper, A;
Houwing, M;
Davies, EG;
Rao, K;
Burns, S;
Morris, E;
Laven, J;
... Nussey, S; + view all
(2020)
Anti-Mullerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens.
Bone Marrow Transplantation
10.1038/s41409-020-0866-9.
Preview |
Text
Burns_Treo RIC paper final copy[85276].pdf - Accepted Version Download (375kB) | Preview |
Abstract
Serum concentrations of Anti-Müllerian hormone (AMH) and Inhibin B were used to assess potential fertility in survivors of childhood haematopoietic stem cell transplantation (HSCT) after three chemotherapy-conditioning regimens of differing intensity. Of 428 patients transplanted between 1990–2012 for leukaemia and immunodeficiency 121 surviving >1 year after a single HSCT were recruited. Group A had a treosulfan-based regimen (low-toxicity); Group B had fludarabine/melphalan (Flu-Mel) (reduced-intensity) and Group C had busulphan/cyclophosphamide (Bu-Cy) (myelo-ablative). Mean age at HSCT and follow-up and length of follow-up were 3.6, 11.8 and 9.9 years. Mean AMH standard deviation scores (SDS) were significantly higher in Group A (−1.047) and Group B (−1.255) than Group C (−1.543), suggesting less ovarian reserve impairment after treosulfan and Flu-Mel than after Bu-Cy. Mean serum AMH concentration was significantly better with treosulfan (>1.0 μg/l) than with Flu-Mel or Bu-Cy. In males, mean Inhibin B SDS was significantly higher in Group A (−0.506) than in Group B (−2.53) and Group C (−1.23) with the Flu-Mel group suffering greatest impairment. In conclusion, a treosulfan-based regimen confers a more favourable outlook for gonadal reserve than Flu-Mel or Bu-Cy in both sexes. Higher values of Inhibin B after Bu-Cy than after Flu-Mel may reflect recovery over time.
| Type: | Article |
|---|---|
| Title: | Anti-Mullerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41409-020-0866-9 |
| Publisher version: | http://dx.doi.org/10.1038/s41409-020-0866-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | BONE-MARROW-TRANSPLANTATION, ACUTE MYELOID-LEUKEMIA, NONENDOCRINE LATE COMPLICATIONS, FOLLICLE-STIMULATING-HORMONE, TOTAL-BODY IRRADIATION, HIGH-DOSE BUSULFAN, OVARIAN-FUNCTION, GONADAL-FUNCTION, CONDITIONING REGIMEN, SERUM CONCENTRATIONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108101 |
Archive Staff Only
 |
View Item |
