Verhaar, BJH;
de Leeuw, FA;
Doorduijn, AS;
Fieldhouse, JLP;
van de Rest, O;
Teunissen, CE;
van Berckel, BNM;
... van der Flier, WM; + view all
(2020)
Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 12
(1)
, Article e12063. 10.1002/dad2.12063.
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Abstract
INTRODUCTION: Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. METHODS: We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. RESULTS: Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. DISCUSSION: Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.
| Type: | Article |
|---|---|
| Title: | Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/dad2.12063 |
| Publisher version: | https://doi.org/10.1002/dad2.12063 |
| Language: | English |
| Additional information: | © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | body mass index, cerebral atrophy, fat free mass, fat mass, magnetic resonance imaging, malnutrition, microbleeds, mild cognitive impairment, nutritional status, white matter hyperintensities |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108407 |
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