Boomsma, JMF;
Exalto, LG;
Barkhof, F;
Chen, CLH;
Hilal, S;
Leeuwis, AE;
Prins, ND;
... TRACE‐VCI study group, .; + view all
(2020)
Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 12
(1)
, Article e12077. 10.1002/dad2.12077.
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Abstract
INTRODUCTION: Prognostication in memory clinic patients with vascular brain injury (eg possible vascular cognitive impairment [VCI]) is often uncertain. We created a risk score to predict poor clinical outcome. METHODS: Using data from two longitudinal cohorts of memory clinic patients with vascular brain injury without advanced dementia, we created (n = 707) and validated (n = 235) the risk score. Poor clinical outcome was defined as substantial cognitive decline (change of Clinical Dementia Rating ≥1 or institutionalization) or major vascular events or death. Twenty‐four candidate predictors were evaluated using Cox proportional hazard models. RESULTS: Age, clinical syndrome diagnosis, Disability Assessment for Dementia, Neuropsychiatric Inventory, and medial temporal lobe atrophy most strongly predicted poor outcome and constituted the risk score (C‐statistic 0.71; validation cohort 0.78). Of note, none of the vascular predictors were retained in this model. The 2‐year risk of poor outcome was 6.5% for the lowest (0‐5) and 55.4% for the highest sum scores (10‐13). DISCUSSION: This is the first, validated, prediction score for 2‐year clinical outcome of patients with possible VCI.
| Type: | Article |
|---|---|
| Title: | Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/dad2.12077 |
| Publisher version: | https://doi.org/10.1002/dad2.12077 |
| Language: | English |
| Additional information: | © 2020 the Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | cognitive decline, death, major vascular event, memory clinic, poor clinical outcome, prediction score, prognosis, vascular cognitive impairment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108408 |
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