Pomiankowski, A;
(2020)
Resistance to Natural and Synthetic Gene Drive Systems.
Journal of Evolutionary Biology
, 33
(10)
pp. 1345-1360.
10.1111/jeb.13693.
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Abstract
Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.
| Type: | Article |
|---|---|
| Title: | Resistance to Natural and Synthetic Gene Drive Systems |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jeb.13693 |
| Publisher version: | https://doi.org/10.1111/jeb.13693 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | CRISPR‐Cas9, fitness costs, meiotic drive, population suppression, selfish genetic elements, sex ratio distorter, transposable element, Wolbachia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108940 |
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