Hodel, AW;
Rudd-Schmidt, J;
Trapani, JA;
Voskoboinik, I;
Hoogenboom, B;
(2020)
Lipid specificity of the immune effector perforin.
Faraday Discussions
10.1039/d0fd00043d.
(In press).
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Abstract
Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and negatively charged lipids scavenge any residual protein before pore formation. Using atomic force microscopy on model membrane systems, we here provide insight into the molecular basis of perforin lipid specificity.
| Type: | Article |
|---|---|
| Title: | Lipid specificity of the immune effector perforin |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d0fd00043d |
| Publisher version: | https://doi.org/10.1039/d0fd00043d |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10108949 |
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