Storm, T;
Burgoyne, T;
Futter, CE;
(2020)
Membrane trafficking in the retinal pigment epithelium at a glance.
Journal of Cell Science
, 133
(16)
, Article jcs238279. 10.1242/jcs.238279.
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Abstract
The retinal pigment epithelium (RPE) is a highly specialised pigmented monolayer sandwiched between the choroid and the photoreceptors in the retina. Key functions of the RPE include transport of nutrients to the neural retina, removal of waste products and water from the retina to the blood, recycling of retinal chromophores, absorption of scattered light and phagocytosis of the tips of the photoreceptor outer segments. These functions place a considerable membrane trafficking burden on the RPE. In this Cell Science at a Glance article and the accompanying poster, we focus on RPE-specific adaptations of trafficking pathways. We outline mechanisms underlying the polarised expression of membrane proteins, melanosome biogenesis and movement, and endocytic trafficking, as well as photoreceptor outer segment phagocytosis and degradation. We also briefly discuss theories of how dysfunction in trafficking pathways contributes to retinal disease.
| Type: | Article |
|---|---|
| Title: | Membrane trafficking in the retinal pigment epithelium at a glance |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/jcs.238279 |
| Publisher version: | https://doi.org/10.1242/jcs.238279 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Melanosome, Membrane trafficking, Phagocytosis, Polarity, Retinal pigment epithelium |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10109288 |
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