Carugo, D;
Lee, JY;
Pora, A;
Browning, RJ;
Capretto, L;
Nastruzzi, C;
Stride, E;
(2016)
Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (mu Mi-REM) technique.
Biomedical Microdevices
, 18
, Article 4. 10.1007/s10544-015-0027-x.
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Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-RE.pdf - Published Version Download (2MB) | Preview |
Abstract
We describe a cost-effective and simple method to fabricate PDMS-based microfluidic devices by combining micromilling with replica moulding technology. It relies on the following steps: (i) microchannels are milled in a block of acrylic; (ii) low-cost epoxy adhesive resin is poured over the milled acrylic block and allowed to cure; (iii) the solidified resin layer is peeled off the acrylic block and used as a mould for transferring the microchannel architecture onto a PDMS layer; finally (iv) the PDMS layer is plasma bonded to a glass surface. With this method, microscale architectures can be fabricated without the need for advanced technological equipment or laborious and time-consuming intermediate procedures. In this manuscript, we describe and validate the microfabrication procedure, and we illustrate its applicability to emulsion and microbubble production.
| Type: | Article |
|---|---|
| Title: | Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (mu Mi-REM) technique |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10544-015-0027-x |
| Publisher version: | https://doi.org/10.1007/s10544-015-0027-x |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Microfabrication . Microfluidic . Microchannel . Micromilling . Pmma . Replica moulding . Pdms . Emulsions . Microbubbles |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10109421 |
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