Gerdes, LA; Janoschka, C; Eveslage, M; Mannig, B; Wirth, T; Schulte-Mecklenbeck, A; Lauks, S; ... Klotz, L; + view all Gerdes, LA; Janoschka, C; Eveslage, M; Mannig, B; Wirth, T; Schulte-Mecklenbeck, A; Lauks, S; Glau, L; Gross, CC; Tolosa, E; Flierl-Hecht, A; Ertl-Wagner, B; Barkhof, F; Meuth, SG; Kümpfel, T; Wiendl, H; Hohlfeld, R; Klotz, L; - view fewer (2020) Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proceedings of the National Academy of Science of the United States of America , 117 (35) pp. 21546-21556. 10.1073/pnas.2003339117.

Preview

Text 21546.full.pdf - Published Version Download (1MB) | Preview

Abstract

The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein level. Despite disease discordance, the immune signatures of MS-affected and unaffected cotwins were remarkably similar. Twinship alone contributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance. Notably, distinct traits in CD4+ effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation.

Download activity - last month

Export as XMLJSONCSV

Download activity - last 12 months

Export as CSVXMLJSON

Downloads by country - last 12 months

Export as CSVXMLJSON

Archive Staff Only

View Item