Jones, AC;
Nicholson, WI;
Smallman, HR;
Browne, DL;
(2020)
A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling.
Organic Letters
, 22
(19)
pp. 7433-7438.
10.1021/acs.orglett.0c02418.
Preview |
Text (Article)
Browne_Mechano_C-S_Accepted.pdf - Accepted Version Download (629kB) | Preview |
Preview |
Text (Correction)
Browne_Mechano_C-S_Correction.pdf - Accepted Version Download (158kB) | Preview |
Abstract
An operationally simple mechanochemical C–S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.
Archive Staff Only
 |
View Item |
