Jeng, J-Y;
Ceriani, F;
Olt, J;
Brown, SDM;
Holley, MC;
Bowl, MR;
Johnson, SL;
(2020)
Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea.
Journal of Physiology
, 598
(19)
pp. 4339-4355.
10.1113/JP280018.
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Abstract
Mammalian cochlear inner hair cells (IHCs) are specialized sensory receptors able to provide dynamic coding of sound signals. This ability is largely conferred by their ribbon synapses, which tether a large number of vesicles at the IHC’s presynaptic active zones, allowing high rates of sustained synaptic transmission onto the afferent fibres. How the physiological and morphological properties of ribbon synapses change with age remains largely unknown. Here, we have investigated the biophysical and morphological properties of IHC ribbon synapses in the ageing cochlea (9–12 kHz region) of four mouse strains commonly used in hearing research: early-onset progressive hearing loss (C57BL/6J and C57BL/6NTac) and ‘good hearing’ strains (C57BL/6NTacCdh23+ and C3H/HeJ). We found that with age, both modiolar and pillar sides of the IHC exhibited a loss of ribbons, but there was an increased volume of those that remained.
| Type: | Article |
|---|---|
| Title: | Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/JP280018 |
| Publisher version: | http://dx.doi.org/10.1113/JP280018 |
| Language: | English |
| Additional information: | © 2020 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Physiology, Neurosciences & Neurology, age-related hearing loss, auditory brainstem responses, calcium channels, cochlea, exocytosis, inner hair cells, mouse, ribbon synapses, AUDITORY-NERVE FIBERS, HEARING-LOSS, CA2+ CHANNELS, PRESYNAPTIC ACTIVITY, TRANSMITTER RELEASE, CALCIUM-DEPENDENCE, CAT COCHLEA, MOUSE MODEL, GUINEA-PIG, AGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10112359 |
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