Moreddu, R;
Elsherif, M;
Adams, H;
Moschou, D;
Cordeiro, MF;
Wolffsohn, JS;
Vigolo, D;
... Yetisen, AK; + view all
(2020)
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis.
Lab on a Chip
, 20
(21)
pp. 3970-3979.
10.1039/d0lc00438c.
Preview |
Text
accepted.pdf - Accepted Version Download (2MB) | Preview |
Abstract
In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and L-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.
| Type: | Article |
|---|---|
| Title: | Integration of paper microfluidic sensors into contact lenses for tear fluid analysis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d0lc00438c |
| Publisher version: | https://doi.org/10.1039/D0LC00438C |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10112461 |
Archive Staff Only
 |
View Item |
