Cao, Q;
Nicholson, WI;
Jones, AC;
Browne, DL;
(2019)
Robust Buchwald-Hartwig amination enabled by ball-milling.
Organic and Biomolecular Chemistry
, 17
(7)
pp. 1722-1726.
10.1039/c8ob01781f.
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Abstract
An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.
| Type: | Article |
|---|---|
| Title: | Robust Buchwald-Hartwig amination enabled by ball-milling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c8ob01781f |
| Publisher version: | https://doi.org/10.1039/c8ob01781f |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. See: https://creativecommons.org/licenses/by/3.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Organic, Chemistry, N-HETEROCYCLIC CARBENES, ARYL CHLORIDES, MECHANOCHEMISTRY, COMPLEXES, PRECATALYST, CATALYSTS, LIGANDS, NHC |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10114327 |
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