Yaghini, Elnaz;
IGA, Arthur M;
Macrobert, Alexander J;
Seifalian, Alexander M;
(2009)
Spectroscopic evaluation of QDs encapsulated with a novel biocompatible polymer for cancer diagnosis.
Head & Neck Oncology
, 1
(Suppl 1)
, Article P7. 10.1186/1758-3284-1-S1-P7.
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Abstract
Quantum dots (QDs) are new class of fluorescent inorganic nanocrystals which have been used for in vitro and in vivo imaging. Their unique optical properties such as broad excitation spectra, narrow emission spectrum and resistance to photobleaching make them ideal for biological labeling. Sentinel lymph node biopsy is a means of ultra-staging cancer metastasis and is now the standard of care in breast cancer surgery. Localisation of sentinel nodes is also important in the treatment of head and neck cancer. Current tracers for SLN biopsy include the blue dye have various limitations that could be overcome by quantum dots that emit in near infrared range (>700 nm). To safely deliver QDs they must be encapsulated in a biocompatible coating. In this study we encapsulate CdTe QDs with new nanocomposite material based on a silsesquioxane modified poly (carbonate-urea) urethane polymer, and evaluated their spectroscopic properties.
| Type: | Article |
|---|---|
| Title: | Spectroscopic evaluation of QDs encapsulated with a novel biocompatible polymer for cancer diagnosis |
| Event: | Scientific Meeting of the Head and Neck Optical Diagnostics Society |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1758-3284-1-S1-P7 |
| Publisher version: | https://doi.org/10.1186/1758-3284-1-S1-P7 |
| Additional information: | © The Author(s). This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Sentinel Lymph Node, Sentinel Lymph Node Biopsy, Fluorescence Lifetime, Biocompatible Coating, Narrow Emission Spectrum |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10114410 |
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