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Reversible DNA micro-patterning using the fluorous effect

Flynn, GE; Withers, JM; Macias, G; Sperling, JR; Henry, SL; Cooper, JM; Burley, GA; (2017) Reversible DNA micro-patterning using the fluorous effect. Chemical Communications , 53 (21) pp. 3094-3097. 10.1039/c7cc00288b. Green open access

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Abstract

We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.

Type: Article
Title: Reversible DNA micro-patterning using the fluorous effect
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7cc00288b
Publisher version: http://dx.doi.org/10.1039/c7cc00288b
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keywords: DNA, Hydrocarbons, Fluorinated, Optical Imaging, Surface Properties
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10114502
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