Choi, S;
Ferrari, G;
Tedesco, FS;
(2020)
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies.
EMBO Molecular Medicine
, Article e12357. 10.15252/emmm.202012357.
(In press).
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Abstract
Directional cell migration is a critical process underlying morphogenesis and post‐natal tissue regeneration. During embryonic myogenesis, migration of skeletal myogenic progenitors is essential to generate the anlagen of limbs, diaphragm and tongue, whereas in post‐natal skeletal muscles, migration of muscle satellite (stem) cells towards regions of injury is necessary for repair and regeneration of muscle fibres. Additionally, safe and efficient migration of transplanted cells is critical in cell therapies, both allogeneic and autologous. Although administration of various myogenic cell types has been done intramuscularly or intravascularly, functional restoration has not been achieved yet in patients with degenerative diseases affecting multiple large muscle. One of the key reasons for this negative outcome is the limited migration of donor cells, which hinders the overall cell engraftment potential. Here, we review mechanisms of myogenic stem/progenitor cell migration during skeletal muscle development and post‐natal regeneration. Furthermore, strategies utilised to improve migratory capacity of myogenic cells are examined in order to identify potential treatments that may be applied to future transplantation protocols.
| Type: | Article |
|---|---|
| Title: | Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/emmm.202012357 |
| Publisher version: | https://doi.org/10.15252/emmm.202012357 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors Published under the terms of the CC BY 4.0 license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | cell migration, cell therapy, muscle regeneration, muscle stem cells, muscular dystrophy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10115834 |
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