Lo, E;
Menezes, L;
Torii, R;
(2019)
On boundary conditions in computation of CT-based FFR: a study integrating pet perfusion images in CFD.
In:
Proceedings of the 6th International Conference on Computational and Mathematical Biomedical Engineering.
(pp. pp. 119-122).
Computational and Mathematical Biomedical Engineering (CMBE): Cardiff, UK.
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Abstract
Sensitivity of CT-based fractional flow reserve (FFR) calculation to inflow and outflow boundary conditions (BCs) was investigated. The inflow investigation focused on the impact of flow pulsatility, and the outflow investigation was on the effect of using patient-specific myocardial perfusion downstream to each coronary branch. The FFRs were computed for 12 patients with various degree of stenosis. CFD simulations using 3D patient-specific anatomical models with patient-specific inflow and outflow conditions indicated that the type of inflow BCs (steady/pulsatile) does not have a significant impact on computed FFRs. The FFRs derived from the two outflow BCs – determined from only vessel morphology and from myocardial perfusion – agreed in general but the difference is larger for severely diseased patients, potentially misleading the treatment. The sensitivity of FFR computations to BCs were shown not too high in general but there are some exceptions where extra care may need to be in place
| Type: | Proceedings paper |
|---|---|
| Title: | On boundary conditions in computation of CT-based FFR: a study integrating pet perfusion images in CFD |
| Event: | 6th International Conference on Computational and Mathematical Biomedical Engineering |
| Location: | Sendai, Japan |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.compbiomed.net/2019/ |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | CT-based computation of FFR, flow pulsatility, patient-specific outflow |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10116753 |
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