Demetriou, E;
Tachrount, M;
Ellis, M;
LINEHAN, J;
Brandner, S;
Shmueli, K;
Farrow, M;
(2019)
A multiparametric study of prion disease.
In:
Proceedings of the ISMRM 27th Annual Meeting & Exhibition 2019.
(pp. p. 2613).
ISMRM: Montréal, QC, Canada.
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Abstract
In this work, we hypothesize that the metabolic changes occurring in the brain of prion-infected mice due to conformational changes of prion protein can be mapped using CEST MRI following previous in vivo work. Our previous findings include reduced Nuclear Overhauser Effect mediated by exchange-relayed signals in thalamus and cortex of prion-infected mice possibly related to up normal prion protein folding. Here we extend our studies by including a rich multipower acquisition scheme for targeting exchange processes falling at different regimes. For understanding the origin of CEST signal alternations T1, T2, and MT maps are included as well as histological findings.
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