Qiu, T;
Teshima, THN;
Hovorakova, M;
Tucker, AS;
(2020)
Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation.
Frontiers in Physiology
, 11
, Article 753. 10.3389/fphys.2020.00753.
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Abstract
The vestibular lamina (VL) is a transient developmental structure that forms the lip furrow, creating a gap between the lips/cheeks and teeth (oral vestibule). Surprisingly, little is known about the development of the VL and its relationship to the adjacent dental lamina (DL), which forms the teeth. In some congenital disorders, such as Ellis-van Creveld (EVC) syndrome, development of the VL is disrupted and multiple supernumerary frenula form, physically linking the lips and teeth. Here, we assess the normal development of the VL in human embryos from 6.5 (CS19) to 13 weeks of development, showing the close relationship between the VL and DL, from initiation to differentiation. In the anterior lower region, the two structures arise from the same epithelial thickening. The VL then undergoes complex morphogenetic changes during development, forming a branched structure that separates to create the vestibule. Changing expression of keratins highlight the differentiation patterns in the VL, with fissure formation linked to the onset of filaggrin. Apoptosis is involved in removal of the central portion of the VL to create a broad furrow between the future cheek and gum. This research forms an essential base to further explore developmental defects in this part of the oral cavity.
| Type: | Article |
|---|---|
| Title: | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2020.00753 |
| Publisher version: | http://dx.doi.org/10.3389/fphys.2020.00753 |
| Language: | English |
| Additional information: | Copyright © 2020 Qiu, Teshima, Hovorakova and Tucker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | dental pathologies, keratin, epithelial differentiation, apoptosis, oral mucosa, human development |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10117244 |
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