Herbert, A;
Barclay, M;
Koo, M;
Rous, B;
Abel, G;
Greenberg, D;
Lyratzopoulos, G;
(2021)
Stage-specific incidence trends of renal cancers in the East of England, 1999-2016.
Cancer Epidemiology
, 71
(Part A)
, Article 101883. 10.1016/j.canep.2020.101883.
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Abstract
Objectives: To determine stage-specific time-trends in renal cancer incidence. Methods: We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation. Results: Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016. Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.
| Type: | Article |
|---|---|
| Title: | Stage-specific incidence trends of renal cancers in the East of England, 1999-2016 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.canep.2020.101883 |
| Publisher version: | https://doi.org/10.1016/j.canep.2020.101883 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10118051 |
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