UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU setting

Kerin, B; Rajakulendran, S; Kullmann, DM; Neligan, A; Walker, MC; (2021) A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU setting. Seizure , 85 pp. 90-94. 10.1016/j.seizure.2020.12.020. Green open access

[thumbnail of Walker_A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU settin_AAM.pdf]
Preview
Text
Walker_A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU settin_AAM.pdf - Accepted Version

Download (362kB) | Preview

Abstract

PURPOSE: Over the last decade, the range of treatments available for the management of super-refractory status epilepticus (SRSE) has expanded. However, it is unclear whether this has had an impact on its high mortality and morbidity. The aim of this study was to investigate whether there has been a change in the outcome of SRSE over time in a neurological intensive care unit (ICU) within a tertiary centre. METHODS: Analysis of a retrospective cohort of 53 admissions from 45 patients to the neurological ICU at the National Hospital for Neurology and Neurosurgery, Queen Square, London, between January 2004 and September 2018. RESULTS: Significant reductions were observed in both duration of SRSE over time and in the time spent in ICU, suggesting that treatment quality has improved over time. A median of four antiseizure drugs (ASDs) were given prior to seizure resolution. In 23 % resolution of SRSE occurred following optimisation of current treatment rather than introduction of a new ASD. The mortality rate was very low at 11 % by 6 months; however, there was no indication of improvement in outcome as all surviving patients had a modified Rankin scale score of 3-5 upon discharge from ICU, classified as moderate-to-severe disability. CONCLUSION: Neither the survival rate nor the outcome score changed significantly over time, suggesting that changes in the treatment of SRSE have had no impact on patient outcome.

Type: Article
Title: A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU setting
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.seizure.2020.12.020
Publisher version: https://doi.org/10.1016/j.seizure.2020.12.020
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Morbidity, Mortality, Outcome, SRSE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10121190
Downloads since deposit
2,556Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item