De Doncker, W;
Ondobaka, S;
Kuppuswamy, A;
(2021)
Effect of transcranial direct current stimulation on post-stroke fatigue.
Journal of Neurology
10.1007/s00415-021-10442-8.
(In press).
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Abstract
Background: Fatigue is one of the most commonly reported symptoms post-stroke, which has a severe impact on the quality of life. Post-stroke fatigue is associated with reduced motor cortical excitability, specifcally of the afected hemisphere. Objective: The aim of this exploratory study was to assess whether fatigue symptoms can be reduced by increasing cortical excitability using anodal transcranial direct current stimulation (tDCS). Methods: In this sham-controlled, double-blind intervention study, tDCS was applied bilaterally over the primary motor cortex in a single session in thirty stroke survivors with high severity of fatigue. A questionnaire-based measure of trait fatigue (primary outcome) was obtained before, after a week and 5 weeks post stimulation. Secondary outcome measures of state fatigue, motor cortex neurophysiology and perceived efort were also assessed pre, immediately post, a week and 5 weeks post stimulation. Results: Anodal tDCS signifcantly improved fatigue symptoms a week after real stimulation when compared to sham stimulation. There was also a signifcant change in motor cortex neurophysiology of the afected hemisphere and perceived efort, a week after stimulation. The degree of improvement in fatigue was associated with baseline anxiety levels. Conclusion: A single session of anodal tDCS improves fatigue symptoms with the efect lasting up to a week post stimulation. tDCS may therefore be a useful tool for managing fatigue symptoms post-stroke. Trial registration: NCT04634864 Date of registration: 17/11/2020–“retrospectively registered”.
| Type: | Article |
|---|---|
| Title: | Effect of transcranial direct current stimulation on post-stroke fatigue |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00415-021-10442-8 |
| Publisher version: | https://link.springer.com/article/10.1007/s00415-0... |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | tDCS, Effort, Fatigue, Perception, Stroke |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10123747 |
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