Marino, A;
Hausenloy, DJ;
Andreadou, I;
Horman, S;
Bertrand, L;
Beauloye, C;
(2021)
AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury.
Free Radical Biology and Medicine
, 166
pp. 238-254.
10.1016/j.freeradbiomed.2021.02.047.
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Abstract
Heart failure is one of the leading causes of death and disability worldwide. Left ventricle remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of cardiac function and predispose to the onset of heart failure. Adenosine monophosphate-activated protein kinase (AMPK) is the universally recognized energy sensor which responds to low ATP levels and restores cellular metabolism. AMPK activation controls numerous cellular processes and, in the heart, it plays a pivotal role in preventing onset and progression of disease. Excessive reactive oxygen species (ROS) generation, known as oxidative stress, can activate AMPK, conferring an additional role of AMPK as a redox-sensor. In this review, we discuss recent insights into the crosstalk between ROS and AMPK. We describe the molecular mechanisms by which ROS activate AMPK and how AMPK signaling can further prevent heart failure progression. Ultimately, we review the potential therapeutic approaches to target AMPK for the treatment of cardiovascular disease and prevention of heart failure.
| Type: | Article |
|---|---|
| Title: | AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.freeradbiomed.2021.02.047 |
| Publisher version: | https://doi.org/10.1016/j.freeradbiomed.2021.02.04... |
| Language: | English |
| Additional information: | Copyright © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | AMPK, Cardiac hypertrophy, HFpEF, HFrEF, Heart Failure, Ischemia, Ischemia/Reperfusion injury, Nox, ROS, Reperfusion |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10123945 |
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