Hill, N. C. W.;
(1992)
Clinical applications of the progesterone receptor antagonist mifepristone during early pregnancy and its application in therapeutic abortion.
Doctoral thesis (M.D), UCL (University College London).
Preview |
Text
Clinical_applications_of_the_p.pdf Download (5MB) | Preview |
Abstract
Mifepristone (RU 38,486) is a new synthetic steroid which is antagonistic to progesterone at the receptor level. Mifepristone has been demonstrated to cause spontaneous abortion of early pregnancies when taken orally. When used in combination with a prostaglandin analogue the termination success rate is increased. The studies performed in this thesis were designed to further investigate the clinical effects of mifepristone in the first and second trimesters of pregnancy, and to study the mechanism of action of the drug. These studies examined: 1) . The efficacy and side-effects of mifepristone (600mg) in combination with a prostaglandin E1 lmg (Gemeprost) pessary for early termination of pregnancy. 2) . The effect of mifepristone on prostaglandin metabolite levels in the first and second trimesters of pregnancy. 3). The effect of mifepristone on progesterone and oestrogen receptor concentrations in the decidua and placenta in early pregnancy. 4). The physiological and clinical effects of progesterone inhibition with mifepristone in the second trimester. 5). The placental transfer of mifepristone during the second trimester and its influence upon maternal and fetal steroid concentrations.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | M.D |
| Title: | Clinical applications of the progesterone receptor antagonist mifepristone during early pregnancy and its application in therapeutic abortion |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Thesis digitised by ProQuest. |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10124030 |
Archive Staff Only
 |
View Item |
