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Supramolecular Coordination Complexes as Optical Biosensors

Dey, N; Haynes, CJE; (2021) Supramolecular Coordination Complexes as Optical Biosensors. Chempluschem , 86 (3) pp. 418-433. 10.1002/cplu.202100004. Green open access

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Abstract

In recent years, luminescent supramolecular coordination complexes (SCCs), including 2D-metallacycles and 3D-metallacages have been utilised for biomolecular analysis. Unlike small-molecular probes, the dimensions, size, shape, and flexibility of these complexes can easily be tuned by combining ligands designed with particular geometries, symmetries and denticity with metal ions with strong geometrical binding preferences. The well-defined cavities that result, in combination with the other non-covalent interactions that can be programmed into the ligand design, facilitate great selectivity towards guest binding. In this Review we will discuss the application of luminescent metallacycles and cages in the binding and detection of a wide range of biomolecules, such as carbohydrates, proteins, amino acids, and biogenic amines. We aim to explore the effect of the structural diversity of SCCs on the extent of biomolecular sensing, expressed in terms of sensitivity, selectivity and detection range.

Type: Article
Title: Supramolecular Coordination Complexes as Optical Biosensors
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cplu.202100004
Publisher version: https://doi.org/10.1002/cplu.202100004
Language: English
Additional information: © 2021 The Authors. ChemPlusChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: biosensors, coordination complexes, fluorescence, imaging, supramolecular chemistry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10124180
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