Li, GH-Y;
Lee, GK-Y;
Au, PC-M;
Chan, M;
Li, H-L;
Cheung, BM-Y;
Wong, IC-K;
... Cheung, C-L; + view all
(2021)
The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.
Osteoporosis and Sarcopenia
10.1016/j.afos.2021.02.004.
(In press).
Preview |
Text
Osteoporosis and Sarcopenia systematic literature review lean mass and mortality.pdf - Published Version Download (551kB) | Preview |
Abstract
Objectives: Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities. / Methods: A systematic review and meta-analysis of lean mass and mortality was conducted. The analysis was stratified by different measurement modalities and health conditions. Pooled hazard ratios were estimated using a random effects model. / Results: This meta-analysis included 188 studies with 98 468 participants. Reduced lean mass measured by BIA, DXA, and CT, was associated with increased risk of mortality with a hazard ratio (HR) of 1.35 (95% CI, 1.21–1.49), 1.18 (95% CI, 1.06–1.30), and 1.44 (95% CI, 1.32–1.57), respectively. Similarly, low lean mass defined by BIA-, DXA-, and CT-measurement was associated with increased risk of mortality, with an HR of 1.81 (95% CI, 1.56–2.10), 1.44 (95% CI, 1.29–1.60), and 1.78 (95% CI, 1.64–1.93). / Conclusions: Reduced and low lean mass were robustly associated with increased mortality in studies using different measurement modalities.
| Type: | Article |
|---|---|
| Title: | The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.afos.2021.02.004 |
| Publisher version: | https://doi.org/10.1016/j.afos.2021.02.004 |
| Language: | English |
| Additional information: | Copyright © 2021 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | DXA, BIA, CT, Mortality, Lean mass |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10125083 |
Archive Staff Only
 |
View Item |
