Lauder, SN;
Vanhaesebroeck, B;
Gallimore, A;
(2021)
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
British Journal of Cancer
10.1038/s41416-021-01285-1.
(In press).
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Abstract
Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.
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