Hansson, O;
Batrla, R;
Brix, B;
Carrillo, MC;
Corradini, V;
Edelmayer, RM;
Esquivel, RN;
... Blennow, K; + view all
(2021)
The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau.
Alzheimer's & Dementia
, 17
(9)
pp. 1575-1582.
10.1002/alz.12316.
Preview |
Text
Zetterberg_Alzheimer s Dementia - 2021 - Hansson - The Alzheimer s Association international guidelines for handling of.pdf Download (313kB) | Preview |
Abstract
The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between‐center differences in pre‐analytical procedures may contribute to variability in measurements across laboratories. To resolve this issue, a workgroup was led by the Alzheimer's Association with experts from both academia and industry. The aim of the group was to develop a simplified and standardized pre‐analytical protocol for CSF collection and handling before analysis for routine clinical use, and ultimately to ensure high diagnostic performance and minimize patient misclassification rates. Widespread application of the protocol would help minimize variability in measurements, which would facilitate the implementation of unified cut‐off levels across laboratories, and foster the use of CSF biomarkers in AD diagnostics for the benefit of the patients.
| Type: | Article |
|---|---|
| Title: | The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12316 |
| Publisher version: | https://doi.org/10.1002/alz.12316 |
| Language: | English |
| Additional information: | Copyright © 2021 Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Cerebrospinal Fluid, CSF, Alzheimer's disease, Biomarkers, Pre‐Analytical, Measurements, Handling, Fresh CSF, Frozen CSF, Amyloid Beta, Diagnosis, Tau |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10126217 |
Archive Staff Only
 |
View Item |
