Paraboschi, I;
Turnock, S;
Kramer-Marek, G;
Musleh, L;
Barisa, M;
Anderson, J;
Giuliani, S;
(2021)
Near-infrared photoimmunoTherapy (NIR-PIT) for the local control of solid cancers: challenges and potentials for human applications.
Critical Reviews in Oncology Hematology
p. 103325.
10.1016/j.critrevonc.2021.103325.
Preview |
Text
1-s2.0-S104084282100113X-main.pdf - Published Version Download (2MB) | Preview |
Abstract
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. However, the mechanisms of action to produce the cytotoxic effects have yet to be fully understood. Herein, we bring together the current knowledge of NIR-PIT from preclinical and clinical studies in a variety of cancers highlighting the key unanswered research questions. Furthermore, we discuss how to enhance the local control of solid cancers using this novel treatment regimen.
Archive Staff Only
 |
View Item |
