Standardization of Uveitis Nomenclature (SUN) Working Group, .;
(2021)
Classification Criteria For Multiple Evanescent White Dot Syndrome.
American Journal of Ophthalmology
, 228
pp. 198-204.
10.1016/j.ajo.2021.03.050.
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Abstract
Purpose: To determine classification criteria for multiple evanescent white dot syndrome (MEWDS). / Design: Machine learning of cases with MEWDS and 8 other posterior uveitides. / Methods: Cases of posterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the infectious posterior/panuveitides. The resulting criteria were evaluated on the validation set. / Results: One thousand sixty-eight cases of posterior uveitides, including 51 cases of MEWDS, were evaluated by machine learning. Key criteria for MEWDS included: 1) multifocal gray white chorioretinal spots with foveal granularity; 2) characteristic imaging on fluorescein angiography (“wreath-like” hyperfluorescent lesions) and/or optical coherence tomography (hyper-reflective lesions extending from retinal pigment epithelium through ellipsoid zone into the retinal outer nuclear layer); and 3) absent to mild anterior chamber and vitreous inflammation. Overall accuracy for posterior uveitides was 93.9% in the training set and 98.0% (95% confidence interval 94.3, 99.3) in the validation set. The misclassification rates for MEWDS were 7% in the training set and 0% in the validation set. / Conclusions: The criteria for MEWDS had a low misclassification rate and appeared to perform sufficiently well for use in clinical and translational research.
| Type: | Article |
|---|---|
| Title: | Classification Criteria For Multiple Evanescent White Dot Syndrome |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ajo.2021.03.050 |
| Publisher version: | https://doi.org/10.1016/j.ajo.2021.03.050 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10126647 |
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