Kamtchum-Tatuene, J;
Mwangalika Kachingwe, G;
Mwandumba, HC;
Solomon, T;
Benjamin, LA;
(2020)
Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study.
eNeurologicalSci
, 20
, Article 100252. 10.1016/j.ensci.2020.100252.
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Abstract
Background and objective: In sub-Saharan Africa, data on prevalence, risk factors and pathobiology of carotid atherosclerosis are scarce. We aimed to investigate the relationship between biomarkers of endothelial dysfunction and carotid atherosclerosis. Methods: Carotid ultrasound was performed in 66 patients. Plasma concentration of ICAM-1, PAI-1, VEGF, and soluble thrombomodulin were measured by ELISA. A univariable logistic regression analysis was performed to study the relationship between carotid atherosclerosis, biomarkers of endothelial dysfunction, and various demographic and clinical parameters of the participants. Results: The mean age of the participants was 58.7 years (95% CI: 54.4-63.1). Carotid atherosclerosis was diagnosed in 39.4% (95% CI: 27.6-52.2). In the univariable logistic regression, the following factors were associated with carotid atherosclerosis: age > 45 years (OR = 12.0, 95% CI: 1.4-98.8, p = .02), hypertension (OR = 3.8, 95% CI: 1.2-12.1, p = .02), and high-level of soluble thrombomodulin (OR = 3.4, 95% CI: 1.2-10.0, p = .02). Conclusions: There is an association between high levels of soluble thrombomodulin and carotid atherosclerosis in Malawian adults. Further studies with a larger sample size are needed to confirm our findings in other African populations.
| Type: | Article |
|---|---|
| Title: | Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ensci.2020.100252 |
| Publisher version: | https://doi.org/10.1016/j.ensci.2020.100252 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Africa, Atherosclerosis, CV, Coefficient of variability, Carotid intima-media thickness, ELISA, Enzyme-linked immunosorbent assay, Endothelial dysfunction, HIV infection, HIV, Human immunodeficiency virus, ICAM-1, Intercellular adhesion molecule 1, PAI-1, Plasminogen activator inhibitor 1, Stroke, VEGF, Vascular endothelial growth factor, cIMT, Carotid intima-media thickness, sTM, soluble thrombomodulin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10127183 |
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