Çitoğlu, S;
Coşkun, ÖD;
Tung, LD;
Onur, MA;
Kim Thanh, NT;
(2021)
DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents.
Nanomedicine
, 16
(11)
pp. 925-941.
10.2217/nnm-2020-0467.
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Abstract
AIM: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. METHODS: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. RESULTS: DMSA functionalized cubic IONPs with an edge length of 24.5 ± 1.9 nm had a specific absorption rate value of 197.4 W/gFe (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 × 10^{10}, 6.6 × 10^{10} and 9.9 × 10^{10} NP/mL for 24, 48 and 72 h. CONCLUSION: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.
| Type: | Article |
|---|---|
| Title: | DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/nnm-2020-0467 |
| Publisher version: | https://doi.org/10.2217/nnm-2020-0467 |
| Language: | English |
| Additional information: | © 2021 Future Science Group. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | HeLa, SAR, cytotoxicity, iron oxide cubic nanoparticles, meso-2,3-dimercaptosuccinic acid (DMSA) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10128464 |
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