Gonzalez-Meljem, JM;
Martinez-Barbera, JP;
(2021)
Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis.
Cellular and Molecular Life Sciences
10.1007/s00018-021-03798-7.
(In press).
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Abstract
Cellular senescence is a process that can prevent tumour development in a cell autonomous manner by imposing a stable cell cycle arrest after oncogene activation. Paradoxically, senescence can also promote tumour growth cell non-autonomously by creating a permissive tumour microenvironment that fuels tumour initiation, progression to malignancy and metastasis. In a pituitary tumour known as adamantinomatous craniopharyngioma (ACP), cells that carry oncogenic β-catenin mutations and overactivate the WNT signalling pathway form cell clusters that become senescent and activate a senescence-associated secretory phenotype (SASP). Research in mouse models of ACP has provided insights into the function of the senescent cell clusters and revealed a critical role for SASP-mediated activities in paracrine tumour initiation. In this review, we first discuss this research on ACP and subsequently explore the theme of paracrine tumourigenesis in other tumour models available in the literature. Evidence is accumulating supporting the notion that paracrine signalling brought about by senescent cells may underlie tumourigenesis across different tumours and cancer models.
| Type: | Article |
|---|---|
| Title: | Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00018-021-03798-7 |
| Publisher version: | https://doi.org/10.1007/s00018-021-03798-7 |
| Language: | English |
| Additional information: | © 2021 Springer Nature Switzerland AG. Part of Springer Nature. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Pituitary tumour, Cancer stem cells, SOX2, WNT/β-catenin, Oncogene-induced senescence, Therapy-induced senescence, Senolytics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10129238 |
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