Marsee, A;
Roos, FJM;
Verstegen, MMA;
Gehart, H;
de Koning, E;
Lemaigre, F;
Forbes, SJ;
... Spee, B; + view all
(2021)
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.
Cell Stem Cell
, 28
(5)
pp. 816-832.
10.1016/j.stem.2021.04.005.
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Abstract
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
| Type: | Article |
|---|---|
| Title: | Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.stem.2021.04.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.stem.2021.04.005 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cell Biology, PLURIPOTENT STEM-CELLS, LONG-TERM EXPANSION, HEPATOCYTE-LIKE CELLS, IN-VITRO EXPANSION, DIRECTED DIFFERENTIATION, MOUSE PANCREAS, ADULT LIVER, CULTURE, WNT, CHOLANGIOCYTES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10130168 |
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