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OnabotulinumtoxinA in Migraine: A Review of the Literature and Factors Associated with Efficacy

Ray, JC; Hutton, EJ; Matharu, M; (2021) OnabotulinumtoxinA in Migraine: A Review of the Literature and Factors Associated with Efficacy. Journal of Clinic Medicine , 10 (13) , Article 2898. 10.3390/jcm10132898. Green open access

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Abstract

The efficacy of onabotulinumtoxinA (OnaB-A) as a preventative treatment for chronic migraine, emerging fortuitously from clinical observation is now supported by class one evidence and over two decades of real-world clinical data. There is still limited ability to predict a clinically meaningful response to OnaB-A for individual patients, however. This review summarises briefly the proposed mechanism of OnaB-A in chronic migraine, the literature of predictors of clinical response, and recent developments in the field.

Type: Article
Title: OnabotulinumtoxinA in Migraine: A Review of the Literature and Factors Associated with Efficacy
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/jcm10132898
Publisher version: http://dx.doi.org/10.3390/jcm10132898
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: botulinum toxin, migraine, predictors of efficacy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10130678
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