Greenhall, GHB; Ushiro-Lumb, I; Pavord, S; Currie, I; Perera, MTPR; Hartog, H; Hill, QA; ... UK Donor VITT Transplant Study Group; + view all Greenhall, GHB; Ushiro-Lumb, I; Pavord, S; Currie, I; Perera, MTPR; Hartog, H; Hill, QA; Mohamed, I; Khurram, MA; Motallebzadeh, R; Jones, G; Marshall, A; Pollok, J-M; Torpey, N; Pettigrew, GJ; Mehra, S; Sharma, H; Calder, F; Kessaris, N; Nath, J; Roy, D; Oniscu, GC; Clancy, M; Santhanakrishnan, K; Mascaro, J; Lim, S; Berman, M; Madden, S; Mumford, L; Mirza, D; Watson, C; McGowan, O; Thorburn, D; Ravanan, R; Hunt, BJ; Callaghan, CJ; Roberts, DJ; Forsythe, J; UK Donor VITT Transplant Study Group; - view fewer (2021) Organ transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia. American Journal of Transplantation 10.1111/ajt.16735. (In press).

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Abstract

Vaccine-induced thrombosis and thrombocytopenia (VITT) may follow immunisation with the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2. Autoantibodies to platelet factor 4 (PF4) may mediate VITT through antibody-dependent platelet activation, though the underlying etiology is uncertain. Anti-PF4 antibodies are also seen in heparin-induced thrombocytopenia, though most cases of VITT do not have prior heparin exposure. More than 20 million people in the United Kingdom (UK) have received the ChAdOx1 nCoV-19 vaccine.

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