Basnett, P;
Matharu, RK;
Taylor, CS;
Illangakoon, U;
Dawson, JI;
Kanczler, JM;
Behbehani, M;
... Roy, I; + view all
(2021)
Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering.
ACS Applied Materials and Interfaces
, 13
(28)
pp. 32624-32639.
10.1021/acsami.0c19689.
Preview |
Text
Harnessing Polyhydroxyalkanoates and Pressurised Gyration for Hard and Soft Tissue Engineering Revised Manuscript05.pdf - Accepted Version Download (10MB) | Preview |
Abstract
Organ dysfunction is a major cause of morbidity and mortality. Transplantation is typically the only definitive cure, challenged by the lack of sufficient donor organs. Tissue engineering encompasses the development of biomaterial scaffolds to support cell attachment, proliferation, and differentiation, leading to tissue regeneration. For efficient clinical translation, the forming technology utilized must be suitable for mass production. Herein, uniaxial polyhydroxyalkanoate scaffolds manufactured by pressurized gyration, a hybrid scalable spinning technique, are successfully used in bone, nerve, and cardiovascular applications. Chorioallantoic membrane and in vivo studies provided evidence of vascularization, collagen deposition, and cellular invasion for bone tissue engineering. Highly efficient axonal outgrowth was observed in dorsal root ganglion-based 3D ex vivo models. Human induced pluripotent stem cell derived cardiomyocytes exhibited a mature cardiomyocyte phenotype with optimal calcium handling. This study confirms that engineered polyhydroxyalkanoate-based gyrospun fibers provide an exciting and unique toolbox for the development of scalable scaffolds for both hard and soft tissue regeneration.
| Type: | Article |
|---|---|
| Title: | Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsami.0c19689 |
| Publisher version: | https://doi.org/10.1021/acsami.0c19689 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Bone, cardiac, fibers, nerve, polyhydroxyalkanoates, pressurized gyration, scaffolds |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Civil, Environ and Geomatic Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10131174 |
Archive Staff Only
 |
View Item |
