Clapp, L;
Giembycz, M;
Heinemann, A;
Jones, RL;
Narumiya, S;
Norel, X;
Sugimoto, Y;
... Yao, C; + view all
(2021)
Prostanoid receptors in GtoPdb v.2021.2.
IUPHAR/BPS Guide to Pharmacology CITE
, 2021
(2)
10.2218/gtopdb/f58/2021.2.
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Abstract
Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [694]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [448]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.
| Type: | Article |
|---|---|
| Title: | Prostanoid receptors in GtoPdb v.2021.2 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2218/gtopdb/f58/2021.2 |
| Publisher version: | https://doi.org/10.2218/gtopdb/f58/2021.2 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-sa/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10131491 |
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