Ruffle, JK;
Hyare, H;
Howard, MA;
Farmer, AD;
Apkarian, AV;
Williams, SCR;
Aziz, Q;
(2021)
The autonomic brain: multi-dimensional generative hierarchical modelling of the autonomic connectome.
Cortex
, 143
pp. 164-179.
10.1016/j.cortex.2021.06.012.
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Abstract
The autonomic nervous system governs the body's multifaceted internal adaptation to diverse changes in the external environment, a role more complex than is accessible to the methods — and data scales — hitherto used to illuminate its operation. Here we apply generative graphical modelling to large-scale multimodal neuroimaging data encompassing normal and abnormal states to derive a comprehensive hierarchical representation of the autonomic brain. We demonstrate that whereas conventional structural and functional maps identify regions jointly modulated by parasympathetic and sympathetic systems, only graphical analysis discriminates between them, revealing the cardinal roles of the autonomic system to be mediated by high-level distributed interactions. We provide a novel representation of the autonomic system — a multidimensional, generative network — that renders its richness tractable within future models of its function in health and disease.
| Type: | Article |
|---|---|
| Title: | The autonomic brain: multi-dimensional generative hierarchical modelling of the autonomic connectome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cortex.2021.06.012 |
| Publisher version: | https://doi.org/10.1016/j.cortex.2021.06.012 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Autonomic nervous system, Parasympathetic nervous system, Sympathetic nervous system, Brain imaging, Brain structure, Brain function, Heart rate variability, Generative networks |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10131917 |
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