Ossenkoppele, R;
Reimand, J;
Smith, R;
Leuzy, A;
Strandberg, O;
Palmqvist, S;
Stomrud, E;
... Hansson, O; + view all
(2021)
Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers.
EMBO Molecular Medicine
, Article e14398. 10.15252/emmm.202114398.
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Abstract
PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)-related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER-2 (n = 400) and ADNI (n = 371). All had tau-PET ([18F]RO948 in BioFINDER-2, [18F]flortaucipir in ADNI) and CSF p-tau181 biomarkers available. Plasma p-tau181 and plasma/CSF p-tau217 were available in BioFINDER-2 only. Concordance between PET, CSF and plasma tau biomarkers ranged between 66 and 95%. Across the whole group, ridge regression models showed that increased CSF and plasma p-tau181 and p-tau217 levels were independently of tau PET associated with higher age, and APOEɛ4-carriership and Aβ-positivity, while increased tau-PET signal in the temporal cortex was associated with worse cognitive performance and reduced cortical thickness. We conclude that biofluid and neuroimaging markers of tau pathology convey partly independent information, with CSF and plasma p-tau181 and p-tau217 levels being more tightly linked with early markers of AD (especially Aβ-pathology), while tau-PET shows the strongest associations with cognitive and neurodegenerative markers of disease progression.
| Type: | Article |
|---|---|
| Title: | Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/emmm.202114398 |
| Publisher version: | http://dx.doi.org/10.15252/emmm.202114398 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Alzheimer's disease, CSF, PET, plasma, tau, POSITRON-EMISSION-TOMOGRAPHY, MILD COGNITIVE IMPAIRMENT, AMYLOID-BETA, CEREBROSPINAL-FLUID, ASSOCIATION WORKGROUPS, DIAGNOSTIC GUIDELINES, NATIONAL INSTITUTE, DEMENTIA, RECOMMENDATIONS, CORTEX |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10132027 |
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