Jones, AC;
Nicholson, WI;
Leitch, JA;
Browne, DL;
(2021)
A Ball-Milling-Enabled Cross-Electrophile Coupling.
Organic Letters
, 23
(16)
pp. 6337-6341.
10.1021/acs.orglett.1c02096.
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Abstract
The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C–C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive setups, in reaction times of 2 h. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.
| Type: | Article |
|---|---|
| Title: | A Ball-Milling-Enabled Cross-Electrophile Coupling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.orglett.1c02096 |
| Publisher version: | https://doi.org/10.1021/acs.orglett.1c02096 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10132087 |
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