Knoppers, BM;
Bernier, A;
Granados Moreno, P;
Pashayan, N;
(2021)
Of Screening, Stratification, and Scores.
Journal of Personalized Medicine
, 11
(8)
, Article 736. 10.3390/jpm11080736.
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Abstract
Technological innovations including risk-stratification algorithms and large databases of longitudinal population health data and genetic data are allowing us to develop a deeper understanding how individual behaviors, characteristics, and genetics are related to health risk. The clinical implementation of risk-stratified screening programmes that utilise risk scores to allocate patients into tiers of health risk is foreseeable in the future. Legal and ethical challenges associated with risk-stratified cancer care must, however, be addressed. Obtaining access to the rich health data that are required to perform risk-stratification, ensuring equitable access to risk-stratified care, ensuring that algorithms that perform risk-scoring are representative of human genetic diversity, and determining the appropriate follow-up to be provided to stratification participants to alert them to changes in their risk score are among the principal ethical and legal challenges. Accounting for the great burden that regulatory requirements could impose on access to risk-scoring technologies is another critical consideration.
| Type: | Article |
|---|---|
| Title: | Of Screening, Stratification, and Scores |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/jpm11080736 |
| Publisher version: | https://doi.org/10.3390/jpm11080736 |
| Language: | English |
| Additional information: | © 2021 MDPI. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | bioethics; cancer screening; law; stratification; personalized medicine; polygenic risk scores |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10132445 |
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